Igishushanyo mbonera cyibikoresho bishya

Kwiteranya kwa molekulari

--umupaka wicyatsi kibisi utarinze kumena no guhuza

Ihame shingiro ryo kwishyira hamwe:

1. Nkureshya nka - gutwara ibintu bisa byo guteranya no gutondekanya, hamwe nibintu bifite ibintu byuzuzanya kugirango bikururane.

2. Ingufu nke cyane—ingendo y'ibintu n'imyitwarire ya molekile bizahora mu buryo buhamye cyane. Ni uburyo amatsinda ya molekile ashyirwa mu byiciro bigezweho.

Mu buryo bwo kwihuza kwa molekile, imiterere ya CP hagati ya molekile ishobora kunoza cyane imikorere ya biyoloji:

1. Buri molekile ifite imiterere yihariye nuburyo bukora, kandi biragoye kugera kubufatanye no kuvura neza bishingiye kubivanga kubuntu kurwego.

2. Haracyariho molekile nyinshi zifite ibikorwa byiza byibinyabuzima byagabanije cyane kwinjiza no kuyikoresha kubera imiterere mibi.

3. Ibintu bifatika byubuvuzi gakondo bwabashinwa birasobanutse cyane kubyerekeye "umwami, abaministre nabafasha", aho kuba hodgepodge yibyiza.

Guhindura imiterere ya supramolecular no guhindura uburyo bwo gusesengura uburyo:

1. Gusuzuma hifashishijwe mudasobwa kugira ngo hamenyekane vuba ibikoresho byabugenewe bitangwa na Cambridge Crystal Data Center.

2. Koresha inyigisho y'imikorere y'ubucucike kugira ngo wige imiterere ya supramolecular n'imiterere y'ihuriro bigenwa n'imbaraga hagati ya molekile, kandi umenye ubwoko bwa supramolecular ari bwo buryo bwo kubaho.

3. Mu gusesengura imiterere yimyitwarire ningorabahizi, imiterere ya supramolecular yari nziza.

4. Kubara ibintu bitandukanye bya supramolecules, harimo amashanyarazi, optique na thermodynamic.

5. Kubara ibintu byerekana ibintu nka molekuline ya spécran.

6.Hifashishijwe tekinoroji ya docking ya tekinoroji, ibibanza byimikoranire hagati yibikoresho fatizo bya supramolecular na proteine ​​bigenewe, kandi uburyo bwimikoranire hagati ya molekile bwasobanuwe mubwimbitse.

Supramolecular eutectic / Ikoranabuhanga ryumunyu Ionic

Ibikoresho bya tekiniki: inganda zambere, kwerekana ibice byiza bya CP bigize ibice bikora kugirango eutectic ikomeze

Ibyiza: kugabanya uburakari, kongera imbaraga, kunoza imikorere, guteza imbere ubwuzuzanye, kunoza ituze

Ingero z'ibigize: aside salicylic, aside uric, aside ferulic, aside glycyrrhizic, adenosine, niacinamide, 4MSK

Ibikoresho bisanzwe byafashwe bivuye kurutonde rwibikoresho byo kwisiga, nyuma yikizamini cyo kugenzura nko kwigana imiti ya kwant, kwigana ibicuruzwa byinshi, kwerekana Gaussiya, optimizasiyo ya KingDraw, MestReNova, FTIR, na NMR, ibicuruzwa byabonetse bifite imiterere-yuburyo butatu ya kirisiti, ihagaze neza, isuku nke, umwanda muke. Irashobora gukemura neza ingingo zibabaza zikoreshwa mubiribwa, ubuvuzi no kwisiga, no kunoza bioavailability n'umutekano wibikoresho bikora.

Tekinoroji yo gukuramo ibikorwa bya supramolecular

Ibiranga ubuhanga: Uruganda rwambere, guhuza tekinoroji yo gucapa molekuline hamwe nudukoko twa supramolecular, gukuramo neza ibimera bikora neza

Ibyiza: Gukuramo amazi hifashishijwe intego, ubushobozi bwo kuyakuramo bwiyongeraho inshuro 5 ugereranije no kuyakuramo alcool, naho kuyakuramo amazi byiyongeraho inshuro 20; nta gutandukanya, kugabanya ikiguzi, Ibikoresho bitera kwinjira mu mazi Ingero: olive (oleuropein, hydroxytyrosol), rhodiola, Phyloporus y'imiti, lily y'amazi yera, micrococcus

Kamere yimbitse ya eutectic solvent (NaDES): Yavumbuwe bwa mbere nabahanga mu isesengura rya metabolomics. Mugihe cyiterambere ryibimera (kumera, kurira), selile zizahita zikora amazi meza cyane adashingiye kumazi na lipide, bisa nuruvange rwa eutectics.

Hashingiwe ku buhanga bugezweho bwo gutandukanya icyatsi, tekinoroji ya membrane ihuriweho, yunganirwa na tekinoroji yo kongera ingufu za ultrasonic / microwave kugirango igere ku bushyuhe buke, igamije, ciency yo hejuru, ireme ryiza nicyatsi kibisi gikuramo ibintu bifatika. Binyuze mumashanyarazi karemano ya supramolecular nkibisubizo bikomoka kumashanyarazi, bikemura ibibazo byinshi nko gukora neza, kugiciro cyinshi hamwe ningorabahizi mugutunganya imyanda ya fytochemiki yakuweho. Byahiswemo supramolecular solvent ifite imikorere ihamye kandi yongerewe imbaraga zo gukemura ibintu bifatika, nanone uburyo bwo kuvoma burashobora kwiyongera inshuro 20.

Tekinoroji ya supramolecular

Ibikoresho bya tekiniki: Inganda zambere, binyuze muri supramolecular solvent ikomatanya iteza imbere kwinjira muri macromolecules / amazi-gushonga / bigoye kwinjiza ibiyigize

Ibyiza bya tekiniki: kuzamura umutekano, kutangiza no kwangiza neza kwinjirira, ingaruka zoguhuza, gukungahaza icyerekezo muri dermis, hamwe na bioavailability byiyongereyeho inshuro 5-7 Ingero zintangarugero: kolagen, Bosein, peptide yumuringa wubururu, hexapeptide, peptide yuzuye, β-glucan.

Kubera ko uburemere bwa molekile ya peptide ikiri nini ugereranije nibindi bikoresho bikora, kwinjira kwuruhu ni bike. Uburyo bumwe bwo kongera imbaraga burakenewe kugirango tunonosore imbaraga zo kwinjiza peptide, kugirango tugere ku ntego nke no gukora neza, kandi bigerweho neza birwanya gusaza.

Mu gusubiza inganda zibabaje cyane zo kwinjira nabi, hydrophilique nyinshi hamwe na bioavailable nkeya ya macromolecules gakondo, ibicuruzwa bya JUNAS Time Particle synthesis ikoresheje chimique chimique ifashwa, irashobora kugera kuri epidermis na dermis zuruhu binyuze mumiyoboro ya trans-selile, intercellular na follicular. Utarinze kwangiza imiterere yuruhu.Bioavailable yibicuruzwa byiyongereyeho inshuro 5, harimo hejuru ya 45% muri dermis, bitangiza imiterere yuruhu. Ingaruka zo kwinjira nigihe cyo gutura byagezweho kunoza intambwe.Iyi niyambere mubwoko bwayo mu nganda.

Ikoranabuhanga rya Supramolecular biocatalyse

Bioenzyme iyobowe na catalizike: umusemburo wa supramolecular ukoreshwa nka substrate kugirango uzamure ibikorwa bya enzyme, uzamura ihitamo rya chiral, kandi ugere ku isuku ryinshi

Ubwubatsi bwa fennel icyatsi kibisi: hitamo ibihingwa biranga, wongere ibikubiye mubintu bikora, formula ya anhydrous, kunoza imikorere muri rusange

Ikoranabuhanga rya reverse micellar fermentation: gusuzuma ubwoko bw'ibimera, guhisha amavuta y'ibimera, ingaruka nyinshi, kunoza imiterere y'uruhu no kongera uburyo bwo kwinjiza

Hashingiwe ku buhanga bwa gene ya recombinant, tekinoroji yintambwe imwe ya tekinoroji hamwe na tekinoroji ya bioenzyme ya catalitiki ya bioenzyme, bacteri zakozwe na genetique zikoreshwa nka catalitiki kugirango tumenye umusaruro mwinshi wibintu bikora:

Muri sisitemu ya supramolecular solvent, enzyme yerekana ibikorwa byinshi, guhitamo no gutuza, gukoresha cyane ibikoresho fatizo byimbuto, umwanda muke mubikorwa, umusaruro woroheje, imikorere yumutekano muke nibikorwa byumusaruro.

Hindura tekinoroji ya micelle fermentation:

byatoranijwe amavuta karemano afite ibiranga Ubushinwa lP yihitiyemo kugirango ikore surfactants ikorwa na bagiteri yakozwe na genetique.lt irateranijwe nkuwitwaye anti-micellar bundle kugirango imenye neza anti-micellar bundle yuzuza ibikoresho bikoresha amazi kugirango ibashe kubona ibintu byinshi, uburambe bwuruhu, nibikorwa byiza, uburambe, nibikorwa byiza.

Ikoranabuhanga rya supramolecular

Ibiranga tekiniki: gufunga liposome, kurekura uturemangingo tw’uruhu ku buryo bwihariye, kurekura utwo dusimba tw’umusatsi ku buryo bwihariye, no kurekura ibintu bitera ububyimbirwe.

Ibyiza: Nanoisation, gutanga neza, kurekura igihe kirekire, kugabanya uburakari, kunoza umutekano, no guteza imbere ubwinjiracyaha

Ingero z'ibigize: astaxanthin, glabridin, vitamine A, peptide y'umuringa w'ubururu, biotine, ceramide, amavuta y'ibimera

Tekinoroji ya Supramolecular microencapsulation ishingiye kuri liposome, emulsiya yamavuta, tekinoroji ya ionic fluid stabilisation, tekinoroji yo kurekura dermal selile, tekinoroji yo kurekura umusatsi, hamwe na tekinoroji yo kurekura ibintu. Mugihe cyo gukora imiyoboro yubwikorezi, ibicuruzwa birashobora gutanga ibikoresho bikora neza. lt ifite igipimo cyiza cyo kwanduza transdermal, igihe kirekire cyo gutura hamwe no guhagarara neza ahantu hagenewe uruhu. Ifite kandi igiciro gito kandi cyiza cyane murwego rwo kwisiga, ibiryo bikora hamwe na farumasi.

Peptide yubuyobozi bwa tekinoroji yo guteranya

Ibikoresho bya tekiniki: inganda zambere, zigamije kugenzura imiterere myinshi yiminyururu ya aminide acide na polypeptide, yegeranye na peptide ngufi, supramolecular polypeptide

Icyerekezo cya tekiniki: Kunoza amphiphilicity, kongera ituze no kurwanya ubushyuhe, kugabanya uburozi hamwe nihungabana ryumubiri, guteza imbere kwinjirira, no guhuza

Ingero z'ibintu bigize: carnosine ya supramolecular, peptide ya poroteyine y'umusemburo

Guteranya poroteyine na peptides ubwabyo ntibikunze kugaragara gusa mu buzima, ahubwo ni n'ikintu cyiza cyane ku mubiri w'umuntu, ndetse ni n'imwe mu nzira nziza yo gukora ibikoresho bya nano-biological. Uburyo bwo guteranya peptides ubwabyo ni uburyo bwo guteranya hierarchical, kandi "imiterere ya aside amine polar zipper" ni ubwoko bushya bw'imiterere ya super-secondary, ituma peptides ziteranya hierarchical kugira ngo zikore aggregates zateguwe.

Kugena icyerekezo cyubunini bwa peptide ngufi birashobora kugerwaho muguhindura hydrophobicity hamwe nuruhande rwishami ryuruhande rwibisigazwa bya hydrophobique.

Ukurikije ububiko bwihariye bwa ProteineDataBank (PDB) bwa Shinehigh Innovation, komatanya nogukurikirana ubushakashatsi bwa sisitemu, imbaraga za molekuline hamwe na comptabilite ya chimie yo kubara kugirango isesengure imiterere ya molekile ya peptide, hanyuma uyihuze na molekile nyinshi-yiteranya. Peptide yonyine yiteranije ifite amphiphilicity hamwe na symmetry nziza, itezimbere cyane peptide itajegajega, ubushobozi bwa transdermal na bioavailability.