Igishushanyo mbonera cy'ibikoresho fatizo bishya

Kwihuza kwa molekile

--ubuhanga bw'ibidukikije butagira isano risenyuka kandi ritazongera guhuza

Ihame ry'ingenzi ryo kwihuza kwa molekile:

1. Gukurura ibintu bisa biteranya kandi bigateranya, n'ibintu bifite imiterere yuzuzanya kugira ngo bikururane.

2. Ingufu nke cyane—ingendo y'ibintu n'imyitwarire ya molekile bizahora mu buryo buhamye cyane. Ni uburyo amatsinda ya molekile ashyirwa mu byiciro bigezweho.

Mu buryo bwo kwihuza kwa molekile, imiterere ya CP hagati ya molekile ishobora kunoza cyane imikorere ya biyoloji:

1. Buri molekile ifite imiterere yayo yihariye n'imikorere yayo, kandi biragoye kugera ku bufatanye no kuvurwa neza hashingiwe ku kuvanga ku buryo bw'ubwisanzure ku rwego rw'imvange.

2. Haracyariho molekile nyinshi zifite imikorere myiza ya biyoloji zagabanyije cyane uburyo zishyirwamo n'uburyo zikoreshwa bitewe n'imiterere yazo mibi.

3. Ibintu bikora mu buvuzi gakondo bw'Abashinwa byibanda cyane ku "mwami, abaminisitiri n'abafasha", aho kuba uruhurirane rw'ibintu byinshi, ni ko byiza kurushaho.

Icyitegererezo cy'uburyo bwo gusesengura no guhindura imiterere ya Supramolecular:

1. Gusuzuma hifashishijwe mudasobwa kugira ngo hamenyekane vuba ibikoresho byabugenewe bitangwa na Cambridge Crystal Data Center.

2. Koresha inyigisho y'imikorere y'ubucucike kugira ngo wige imiterere ya supramolecular n'imiterere y'ihuriro bigenwa n'imbaraga hagati ya molekile, kandi umenye ubwoko bwa supramolecular ari bwo buryo bwo kubaho.

3. Mu gusesengura imiterere y'ingaruka n'uburemere, imiterere ya supramolecular yanogejwe.

4. Kubara imiterere itandukanye ya supramolekyuli, harimo imiterere y'amashanyarazi, optique na thermodynamic.

5. Kubara imiterere ya spectral nka molekile na energy spectrum.

6. Binyuze mu ikoranabuhanga ryo gufunga molekile, ahantu hahurira ibikoresho fatizo bya supramolecular na poroteyine zigamije hateganyijwe, kandi uburyo bwo guhuza molekile busobanurwa mu buryo bwimbitse.

Ikoranabuhanga rya Supramolecular eutectic / Ionic salt

Ibiranga tekiniki: iya mbere mu nganda, gusuzuma ibice byiza bya CP by'ibice bikora kugira ngo bikomeze eutectic

Ibyiza: kugabanya uburibwe, kongera ubushobozi bwo gushonga, kunoza imikorere, guteza imbere ubushobozi bwo kwinjira mu mubiri, kunoza uburyo bwo gutuza

Ingero z'ibintu bigize: aside salicylic, aside urique, aside ferulic, aside glycyrrhizic, adenosine, niacinamide, 4MSK

Ibintu karemano bikora neza byakuwe mu kataloge y'ibikoresho fatizo byo kwisiga, nyuma y'ibizamini byo kugenzura nka simulation ya quantum chemical, high-throughput screening, Gaussian optimization, KingDraw, MestReNova, FTIR, na NMR, ibicuruzwa byabonetse bifite imiterere myiza ya kristale ifite imiterere itatu, ihamye, isuku nyinshi, umwanda muke. Bishobora gukemura neza ibibazo by'ibikoresho fatizo bikoreshwa mu biribwa, mu miti no mu mavuta yo kwisiga, no kunoza uburyo ibintu fatizo biboneka n'umutekano wabyo.

Ikoranabuhanga ryo gukuramo ibikorwa bya Supramolecular

Ibiranga ikoranabuhanga: Icya mbere mu nganda, ni uguhuza ikoranabuhanga ryo gushyira mu bikorwa imashini za molekile n'ibintu karemano bisukura molekile, gukuramo neza ibintu bikora mu bimera

Ibyiza: Gukuramo amazi hifashishijwe intego, ubushobozi bwo kuyakuramo bwiyongeraho inshuro 5 ugereranije no kuyakuramo alcool, naho kuyakuramo amazi byiyongeraho inshuro 20; nta gutandukanya, kugabanya ikiguzi, Ibikoresho bitera kwinjira mu mazi Ingero: olive (oleuropein, hydroxytyrosol), rhodiola, Phyloporus y'imiti, lily y'amazi yera, micrococcus

Umusemburo karemano w’ibinyabutabire birebire (NaDES): Wavumbuwe bwa mbere n’abahanga mu isesengura rya metabolomike y’ibimera. Mu byiciro bimwe na bimwe by’iterambere ry’ibimera (gukura, kubika amazi), uturemangingo tuzahita dukora amazi afite umuvuduko mwinshi utari mu mazi na lipide, nk’uruvange rwa eutectics.

Ishingiye ku ikoranabuhanga rigezweho ryo gutandukanya icyatsi kibisi, ikoranabuhanga rya membrane rihuriweho, ryuzuzwa n'ikoranabuhanga ryo kongera ingufu za ultrasound / micro-onde kugira ngo hagerwe ku bushyuhe buke, bugamije, bugezweho, bwiza kandi bukomoka ku cyatsi kibisi. Binyuze muri solvent karemano ya supramolecular nk'umusemburo wo gukuramo neza, ikemura ibibazo byinshi nko gukora neza, guhenda cyane no kugorwa no kugarura amazi myanda mu gusohora phytochemical gakondo. Imisemburo ya supramolecular yakuwemo yatoranijwe bitewe n'imikorere yayo. Umusemburo wa supramolecular watoranijwe ufite imikorere ihamye kandi urushaho gushonga mu bikoresho bikora, kandi imikorere yo gukuramo ishobora kwiyongeraho inshuro 20.

Ikoranabuhanga ryo kwinjira mu buryo bwa Supramolecular synergistic

Ibiranga tekiniki: Inganda za mbere, binyuze mu mushongi wa supramolecular, zifasha mu guhuza ibice by'uturemangingo twinshi/bishongera mu mazi/bigoye kwinjiza ibintu

Ibyiza bya tekiniki: kunoza uburyo bwo guhagarara, kongera ubushobozi bwo kwinjira mu mubiri mu buryo butangiza kandi bunoze, ingaruka nziza zo guhuza ibikorwa, kongera icyerekezo mu ruhu, no kuba umubiri uboneka byiyongeraho inshuro 5-7. Ingero z'ibikubiye muri urwo ruhererekane: kolajeni, Bosein, peptide y'umuringa w'ubururu, hexapeptide, peptide ivanze, β-glucan.

Kubera ko uburemere bwa molekile ya peptide bukiri bunini ugereranije n'ibindi bintu bikora, kwinjira mu ruhu ni bike cyane. Hari uburyo bwo kongera ubushobozi bwo kwinjira mu ruhu kugira ngo hongerwe uburyo bwo kwinjiza peptide mu ruhu, kugira ngo habeho ubushobozi buke kandi bugire ingaruka nziza, kandi habeho uburyo bwiza bwo kurwanya gusaza.

Kubera ko urwego rw'inganda rufite ikibazo cyo kutagira ubushobozi bwo kwinjira neza, ubushobozi bwo kunyura mu mazi menshi no kutagira ubushobozi bwo kubaho bw'uturemangingo dusanzwe, JUNAS Time Particle products synthesis hifashishijwe quantum chemistry, ishobora kugera mu buryo butaziguye ku ruhu binyuze mu nzira za trans-cellular, intercellular na follicular sweat ducts. Hatabayeho kwangiza imiterere y'uruhu. Kuboneka kw'uturemangingo kwiyongeraho inshuro 5, harimo n'ibirenze 45% muri dermis, hatabayeho kwangiza imiterere y'uruhu. Ingaruka zo kwinjira no kumara igihe byagezweho ku ntambwe ikomeye. Iyi ni yo ntambwe ya mbere mu bwoko bwayo mu nganda.

Ikoranabuhanga rya Supramolecular biocatalysis

Katalyse iyobowe na Bioenzyme: ibinyabutabire bya supramolecular bikoreshwa nk'ibinyabutabire kugira ngo byongere imikorere ya enzyme, byongere uburyo bwo guhitamo chiral, kandi bigere ku buziranenge bwo hejuru.

Gutunganya ubushyuhe bw'icyatsi kibisi cya fennel: hitamo ibimera byihariye, wongere ingano y'ibintu bikora, formula idafite amazi, wongere imikorere muri rusange.

Ikoranabuhanga rya reverse micellar fermentation: gusuzuma ubwoko bw'ibimera, guhisha amavuta y'ibimera, ingaruka nyinshi, kunoza imiterere y'uruhu no kongera uburyo bwo kwinjiza

Hashingiwe ku ikoranabuhanga rya recombinant gene, ikoranabuhanga rya one-step gene cloning hamwe n'ikoranabuhanga rya high-density bioenzyme catalytic, bagiteri zahinduwe mu ikoranabuhanga zikoreshwa nk'abatwara catalytic kugira ngo bakore ibintu bifatika ku rwego runini:

Mu rwego rwa sisitemu yo gushonga ya supramolecular, iyi enzyme igaragaza imikorere yo hejuru, guhitamo no guhagarara neza, ikoreshwa cyane ry'ibikoresho fatizo bya substrate, umwanda muke mu ikorwa, imiterere yoroheje y'ingaruka, imikorere myiza y'umutekano n'imikorere myiza y'umusaruro.

Ikoranabuhanga ryo gushyushya micelle mu buryo bwa reverse:

Amavuta karemano yatoranijwe afite imiterere y’Abashinwa lP yagenewe gukora surfactants binyuze mu bikorwa bya bagiteri zahinduwe mu ikoranabuhanga.lt iteranywa nk'ifatabuguzi ry'ipaki irwanya micellar kugira ngo ikoreshwe mu gupfunyika ibintu bikora bishonga mu mazi kugira ngo igere ku bintu byinshi bikoreshwa, uburambe bwiza ku ruhu, n'ubushobozi butangaje, uburambe, n'ubushobozi bugaragara.

Ikoranabuhanga rya Supramolecular microcapsulation

Ibiranga tekiniki: gufunga liposome, kurekura uturemangingo tw’uruhu ku buryo bwihariye, kurekura utwo dusimba tw’umusatsi ku buryo bwihariye, no kurekura ibintu bitera ububyimbirwe.

Ibyiza: Gushyira mu buryo bwa nano, gutanga neza, kurekura bimara igihe kirekire, kugabanya uburibwe, kunoza uburyo bwo gutuza no gutuma amazi yinjira neza.

Ingero z'ibintu bigize: astaxanthin, glabridin, vitamine A, peptide y'umuringa w'ubururu, biotin, ceramide, amavuta y'ingenzi y'ibimera

Ikoranabuhanga rya Supramolecular microencapsulation rishingiye kuri liposome, emulsion y'ibinure, ikoranabuhanga ryo kubungabunga amazi ya ionic, ikoranabuhanga ryo kurekura uturemangingo tw'uruhu, ikoranabuhanga ryo kurekura uturemangingo tw'umusatsi, n'ikoranabuhanga ryo kurekura uturemangingo tw'umusatsi. Mu gukora imiyoboro y'ubwikorezi bw'ubukorano, iki gicuruzwa gishobora gutanga ibikoresho bikora neza. Gifite umuvuduko mwiza wo kwinjiza uturemangingo mu mubiri, kimara igihe kirekire kandi gihamye neza aho uruhu ruherereye. Gifite kandi ikiguzi gito kandi gifite akamaro kanini mu bijyanye n'ubwiza, ibiribwa bikora neza n'imiti.

Ikoranabuhanga ryo kwihuza rya Peptide hierarchical

Ibiranga tekiniki: uburyo bwa mbere bwo kugenzura imiterere y’ibice byinshi by’iminyururu ya aside amine na polipeptide, peptide ngufi ziteranyirijwe hamwe, polipeptide zo hejuru

Icyerekezo cya tekiniki: Kunoza ubushobozi bwo kuzenguruka mu kirere, kongera ubushobozi bwo kudahungabana no kurwanya ubushyuhe, kugabanya uburozi n'ihungabana ry'ubudahangarwa bw'umubiri, guteza imbere uburyo bwo kwinjiza ibintu mu mubiri no guhuza ibikorwa byabyo.

Ingero z'ibintu bigize: carnosine ya supramolecular, peptide ya poroteyine y'umusemburo

Guteranya poroteyine na peptides ubwabyo ntibikunze kugaragara gusa mu buzima, ahubwo ni n'ikintu cyiza cyane ku mubiri w'umuntu, ndetse ni n'imwe mu nzira nziza yo gukora ibikoresho bya nano-biological. Uburyo bwo guteranya peptides ubwabyo ni uburyo bwo guteranya hierarchical, kandi "imiterere ya aside amine polar zipper" ni ubwoko bushya bw'imiterere ya super-secondary, ituma peptides ziteranya hierarchical kugira ngo zikore aggregates zateguwe.

Kugenzura urwego rw'ingano ya peptide ngufi bishobora kugerwaho binyuze mu guhindura uburyo bwo gusiba amazi n'imirongo y'uruhererekane rw'ibisigazwa bya hydrophobic.

Hashingiwe ku bubiko bwihariye bwa Shinehigh Innovation bwa ProteinDataBank (PDB), bihuzwa n'isuzuma ryimbitse, imiterere ya molekile n'ibarura rya quantum chemistry kugira ngo hasesengurwe imiterere ya molekile za peptide, hanyuma bihuzwe na molekile zikora cyane. Guhindura ubwoko, umubare n'aho aside amine ziri hagati ya molekile za peptide kugira ngo bihindure imiterere yazo yihariye, bityo binoze ubushobozi bwa molekile bwo kwishyira hamwe. Menya uburyo peptide zishyirwa hamwe zigenzurwa. Peptide yishyize hamwe ifite ubushobozi bwo kuzamuka no kungana neza, ibyo bikaba binongera cyane ubushobozi bwa peptide, ubushobozi bwo kwanduza uruhu no kuba umuntu afite ubuzima bwiza.