RJMPDRN®REC igaragaza iterambere rikomeye mu bintu byo kwisiga bishingiye kuri aside nucleique, itanga PDRN ya salmon ihuza ibinyabuzima binyuze mu ikoranabuhanga rya biotechnology. PDRN gakondo ikomoka ahanini muri salmon, inzira igengwa n'ibiciro biri hejuru, itandukaniro ry'ubwoko bwose, n'ubuziranenge buke. Byongeye kandi, kwishingikiriza ku mutungo kamere biteza impungenge ku kubungabunga ibidukikije kandi bikagabanya ubushobozi bwo kwaguka kugira ngo hahuzwe n'izamuka ry'ibiciro ku isoko.
RJMPDRN®REC ikemura ibi bibazo ikoresheje ubwoko bwa bagiteri bwakozwe mu buryo bwa tekiniki kugira ngo ikore ibice bya PDRN byibasiwe, bityo ikanagenzura ikorwa ryayo mu gihe ikomeza kuba nziza kandi ikagabanya ingaruka ku bidukikije.
Ubu buryo bwo kongera guhuza butuma habaho imiterere nyayo y'imikorere y'utunyangingo, bigatuma habaho ibikoresho bya aside nucleic byagenewe ingaruka zihariye za bioactive. Uburemere bwa molekile n'imiterere y'ibice bigenzurwa cyane, byongera ubwinshi n'ubwinjirire bw'uruhu. Nk'ikintu kidakoreshwa mu nyamaswa, RJMPDRN®REC ihuza n'amahame mpuzamahanga agenga ibidukikije, yongera kwemerwa kw'isoko mu turere tw’ingenzi. Uburyo bwo gukora bukurikiza amahame y’ubuziranenge, hakoreshejwe uburyo bwo gushyushya no gutunganya butanga ubuziranenge buhamye, ubuziranenge buhanitse, kandi butanga umusaruro wizewe—bikemura ikiguzi, uruhererekane rw’ibicuruzwa, n’ibibazo by’ibidukikije byo gucukura ibicuruzwa bisanzwe.
Mu rwego rwa fisikemikemike, RJMPDRN®REC ni ifu yera, ishongeshwa n'amazi igizwe na ADN ifite RNA ntoya, ikomoka kuri salmon PDRN sequences, kandi ifite pH iri hagati ya 5.0–9.0. Ishyirwa mu cyiciro cy'ibinyabutabire byo mu rwego rwo kwisiga bikwiye gukoreshwa mu mavuta yo mu rwego rwo hejuru, amavuta yo kwisiga, uduce tw'amaso, udupfukamunwa, n'izindi formulaires nziza zo kwita ku ruhu. Ubushakashatsi bwakozwe muri vitro bwagaragaje umutekano wayo n'ubushobozi bwayo ku gipimo cya 100–200 μg/mL, bufasha ikwirakwira ry'uturemangingo no kurwanya ububyimbirwe budafite uburozi bwa cytotoxic.
Inyigo ku mikorere myiza zigaragaza imikorere myiza ya RJMPDRN®REC. Yongera cyane ukwimuka kwa fibroblast, ikagera ku gipimo cyo kwiyongera kwa 131% mu masaha 41 ugereranije n'uburyo bwo kugenzura. Ku bijyanye no gukora kolajeni, RJMPDRN®REC itera kolajeni yo mu bwoko bwa I ku bantu inshuro 1.5 na kolajeni yo mu bwoko bwa III ku nshuro 1.1 ugereranije n'iy'abayigenzura, ikaba irusha PDRN isanzwe ikomoka kuri salmon. Byongeye kandi, ibuza cyane ibintu bitera ubushyuhe nka TNF-α na IL-6. Iyo ihujwe na hyaluronate ya sodium, , RJMPDRN®REC igaragaza ingaruka nziza ku ruhu, yongera ukwimuka kw'uturemangingo, bigaragaza ko hari ubushobozi bukomeye bwo gufatanya mu kuvugurura no kurwanya gusaza k'uruhu.
Muri make, RJMPDRN®REC ikora intambwe iva ku gukuramo ibintu gakondo kugeza ku guhuza ikoranabuhanga rya biotechnological, itanga ubundi buryo bwo kongera gukoreshwa, busukuye cyane, kandi burambye bwo kwita ku ruhu rwo ku rwego rwo hejuru. Ifite imikorere myiza, umutekano, no kwaguka, bituma iba nk'ikintu cy'ingenzi mu gukora ibikoresho byo kwisiga bigamije kurwanya gusaza, gusana uruhu, no kubungabunga ubuzima bw'uruhu muri rusange, bihuye neza n'uburyo ibintu byo kwisiga bihora bikenerwa kandi byemejwe na siyansi.
Kanda hano kugira ngo umenye byinshi kuri iki gicuruzwa.
Igihe cyo kohereza: Kanama-28-2025